 | 职务 | 理学博士 | ||
| 职称 | 副研究员 | |||
| 联系方式 | yuhuang6y@163.com | |||
| 研究方向 | 血栓疾病的纳米诊断与靶向治疗、及其计算机模拟研究 | |||
| 个人简介 | ||||
| 学术经历 2021–至今 上海交通大学医学院附属第六人民医院 副研究员（硕士生导师） 2017–2021 英国帝国理工学院 化工系 博士后 研究方向 血栓疾病的纳米诊断与靶向治疗、及其多物理场建模和数值模拟研究 学术兼职 1. 担任国际学术期刊《Brain X》青年编委 2. 担任国际期刊《Frontiers in Chemistry》客座编辑 3. 英国皇家化学会（RSC）会员、中国化学会（CCS）会员、英国Future Vaccine Manufacturing Research Hub成员 4. 上海市放射学会分子影像学组成员 5. 上海市放射学会医工交叉学组成员 | ||||
| 成果与奖项 | ||||
| 主攻血栓疾病的纳米诊断与治疗及其计算机模拟研究，以第一/通讯作者在Science Advances等杂志发表论文超过20篇，获得上海市海外领军人才、上海市浦江人才、九龙医学青年人才等计划。先后主持国自然、市科委等各级项目，授权国际PCT专利和发明专利3项。获得Sir William Wakeham Award、International Society of Fibrinolysis and Proteolysis Tr**el Award等荣誉。 主要论文 [1] Fibrinogen-mimicking, multiarm nanovesicles for human thrombus-specific delivery of tPA and targeted thrombolytic therapy. Science Advances, 2021, 7, eabf9033.（第一作者） [2] Honeybee-mimicking microenvironment-responsive theranostic nanovesicles for enhanced magnetic resonance imaging and targeted thrombolytic therapy. Journal of Controlled Release, 2026, 391, 114630. （第一作者） [3] Cellular and molecular mechanisms of thrombosis and thrombus-targeted thrombolytic strategies. Materials Today Bio, 2025, 35, 102534. (通讯作者) [4] Endothelium-targeted NF-κB siRNA nanogel for magnetic resonance imaging and visualized-anti-inflammation treatment of atherosclerosis. Biomaterials, 2025, 314, 122897. (通讯作者) [5] Balloon-like biomimetic erythrocyte vesicles potentiate photodynamic therapy for inducing immunogenic cell death. Chemical Engineering Journal. 2024, 500, 157406. (通讯作者) [6] A fibrinogen-mimicking, activated-platelet-sensitive nanocoacervate enhances thrombus targeting and penetration of tissue plasminogen activator for effective thrombolytic therapy. Advanced Healthcare Materials, 2022, 21, 2201265. (第一作者兼通讯作者) [7] An activated-platelet-sensitive nanocarrier enables targeted delivery of tissue plasminogen activator for effective thrombolytic therapy. Journal of Controlled Release, 2019, 300, 1-12.（第一作者） [8] Selective binding of cationic fibrinogen-mimicking chitosan nanoparticles to activated platelets and efficient drug release for antithrombotic therapy. International Journal of Biological Macromolecules, 2024, 131742. (第一作者兼通讯作者) [9] Fibrinogen binding to activated platelets and its biomimetic thrombus-targeted thrombolytic strategies. International Journal of Biological Macromolecules, 2024, 17876. (第一作者兼通讯作者) [10] Combining two-photon-activated FRET and near-infrared photothermal effect of unimolecular micelles for enhanced photodynamic therapy. ACS Nano, 2016, 10, 10489.（第一作者） [11] Color-convertible unimolecular micelle-based activatable fluorescent probe for tumor-specific detection and imaging in vitro and in vivo. Small, 2017, 13, 1604062.（第一作者） [12] A redox-responsive, in-situ polymerized polyplatinum (IV)-coated gold nanorod as an amplifier of tumor accumulation for enhanced thermo-chemotherapy. Biomaterials, 2021, 266, 120400.（通讯作者） [13] Redox-responsive peptide-based complex coacervates as delivery vehicles with controlled release of proteinous drugs. Communications Chemistry, 2023, 7402496.（通讯作者） [14] A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release. Chemical Communications, 2019, 55, 6735-6738.（第一作者） [15] A pH/Redox-dual responsive, nanoemulsion-embedded hydrogel for efficient oral delivery and controlled release of magnesium ions. Journal of Materials Chemistry B, 2021, 9, 1888-1895.（第一作者） | ||||