 | ||||
| 职称 | 研究员 | |||
| 联系方式 | joyzheng99@sjtu.edu.cn | |||
| 研究方向 | 病症的多模态研究 | |||
| 个人简介 | ||||
| 上海交通大学医学院附属第六人民医院，研究员，博士生导师。国家自然科学基金优秀青年，上海市科委青年科技人才，上海交通大学医学院三八红旗手。中国生物物理学会肠道菌群分会、代谢组学分会青年委员。上海交通大学药学院博士，美国北卡罗莱纳大学访问学者。 长期从事基于代谢组学技术的生物标志物发现和药物研发，肠道菌群-胆汁酸互作在代谢性疾病中的作用机制。研究成果多次以第一或通讯作者在Cell Metabolism, Science Translational Medicine, Nature Communications等顶级学术期刊发表论文。研究被Science杂志收录十大科技突破之一，被Cell Metabolism杂志收录于胰岛素发现100周年特刊。 | ||||
| 成果与奖项 | ||||
| 代表性论文
1. Mingliang Zhao, Zhenxing Ren, Aihua Zhao, Yajun Tang, Junliang Kuang, Mengci Li, Tianlu Chen, Shouli Wang, Jieyi Wang, Huiheng Zhang, Jijun Wang, Tianhong Zhang, Jiahui Zeng, Xiaohua Liu, Guoxiang Xie, Penghong Liu, Ning Sun, Tianhao Bao, Tongtong Nie, Jingchao Lin, Ping Liu, Yuanyi Zheng, Xiaojiao Zheng*, Tiemin Liu*, Wei Jia*. Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity. Cell Metabolism. 2024. 36(5):1000-1012. 2. Wei Jia*, Yitao Li, Kenneth C P Cheung, Xiaojiao Zheng*. Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis. Science China Life Sciences. 2024. 67(5):865-878. 3. Junliang Kuang, Jieyi Wang, Yitao Li, Mengci Li, Mingliang Zhao, Kun Ge, Dan Zheng, Kenneth C.P. Cheung, Boya Liao, Shouli Wang, Tianlu Chen, Yinan Zhang, Congrong Wang, Guang Ji, Peng Chen, Hongwei Zhou, Cen Xie, Aihua Zhao, Weiping Jia*, Xiaojiao Zheng*, Wei Jia*. Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis. Cell Metabolism. 2023. 35(10):1752-1766.e8. (Nature Reviews Gastroenterology & Hepatology和Nature Reviews Endocrinology作为研究亮点专题报道) 4. Mengci Li, Shouli Wang, Yitao Li, Mingliang Zhao, Junliang Kuang, Dandan Liang, Jieyi Wang, Cynthia Rajani, Xinran Ma, Yajun Tang, Zhenxing Ren, Tianlu Chen, Aihua Zhao, Cheng Hu, Chengxing Shen, Ping Liu, Xiaojiao Zheng*, Wei Jia*. Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice. Nature Communications. 2022. 13(1):2060. (ESI前1%高被引论文) 5. Xiaojiao Zheng#, Tianlu Chen#, Runqiu Jiang#, Aihua Zhao#, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lu, Weiping Jia*, Changtao Jiang*, Wei Jia*. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metabolism. 2021. 33(4):791-803. (收录Cell Metabolism胰岛素发现100周年特刊) (ESI前1%高被引论文) 6. Xiaojiao Zheng#, Tianlu Chen#, Aihua Zhao#, Zhangchi Ning#, Junliang Kuang, Shouli Wang, Yijun You, Yuqian Bao, Xiaojing Ma, Haoyong Yu, Miao Jiang, Mengci Li, Xiaolong Han, Meilin Wei, Yitao Li, Kun Ge, Cynthia Rajani, Guoxiang Xie, Cheng Hu, Aiping Lu*, Weiping Jia*, Wei Jia*. Hyocholic acid species as novel biomarkers for metabolic disorders. Nature Communications. 2021. 12(1):1487. 7. Wei Jia*, Meilin Wei, Cynthia Rajani, Xiaojiao Zheng*. Targeting The alternative bile acid synthetic pathway for metabolic diseases. Protein & Cell. 2021. 12(5):411-425. 12. Wei Jia*, Cynthia Rajani, Hongxi Xu, Xiaojiao Zheng*. Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma. Protein & Cell. 2021. 12(5):374-393. 8. Xiaojiao Zheng, Fengjie Huang, Aihua Zhao, Sha Lei, Yunjing Zhang, Guoxiang Xie, Tianlu Chen, Chun Qu, Cynthia Rajani, Bing Dong, Defa Li, Wei Jia*. Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice. BMC Biology. 2017. 15(1):120. 9. Xiaojiao Zheng#, Aihua Zhao#*, Guoxiang Xie, Yi Chi, Linjing Zhao, Houkai Li, Congrong Wang, Yuqian Bao, Weiping Jia, Micheal Luther, Mingming Su, Jeremy K Nicholson, Wei Jia*. Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine. 2013. 5(172): 172ra22. (收录Science杂志当年十大科技突破典型研究案例，Nature作为研究亮点专题报道) 奖项：上海市自然科学奖二等奖 近5年主持项目： 国家科技重大专项(2023ZD0507602） 国家自然科学基金优秀青年科学基金项目(82122012) 国家自然科学基金区域创新发展联合基金项目(U24A20797) 国家自然科学基金面上项目(82470853) | ||||