同济大学附属妇产科医院生殖医学中心主任**、胚胎实验室负责人中国优生科学协会理事

中国优生科学协会生殖遗传与胚胎学专委会秘书长/副主任委员

主要研究方向：1.高龄及环境因素对植入前胚胎发育及子代健康的影响

2.配子发生及胚胎发育的表观调控机制研究

3.人工智能在**优选中的临床应用4.肠道菌群及代谢物调控肥胖女性生殖功能的机制研究

郭毅博士从事人类辅助生殖技术胚胎实验室的临床、科研及教学工作近15年。临床研究主要致力于人工智能在**/胚胎优选中的临床应用及**生物标记物的筛选，基础研究聚焦于高龄及环境因素对配子及植入前胚胎表观修饰的影响、肠道菌群及代谢物调控肥胖女性生殖功能的机制研究。

主持项目

1.高龄雄性**tsRNA通过调控早期胚胎基因表达介导子代焦虑样行为发生的机制研究. 国家自然科学基金 面上项目    

2.高龄****miRNA表达谱异常及其在子代自闭症谱系障碍（ASD）发生中的作用和机制研究.国家自然科学基金 青年项目  

3.比较纺锤体观察法与传统极体法对短时授精后部分**失败患者的治疗结局:一项随机双盲对照研究. 中华医学会  

4.基于人工智能的**优选系统的研发. 

上海市第一妇婴保健院发表文章:

1. Junting Xu #, Qiaoling Wang #, Xianting Jiao #, Pengcheng Kong, Siyu Chen,  Wanli Yang, Wenqiang Liu, Kunming Li*, Xiaoming Teng*, Yi Guo*. Association between perfluorooctanoic acid-related poor embryo quality and metabolite alterations in human follicular fluid during IVF:A Cohort Study. Environmental Health Perspectives. 2025 Jun;133(6):67017.

2.  Li J#, Liu Y#, Kong P, Chang Q, Chen S, Yang W, Liu W*, Teng X*, Guo Y*: Impact of DNAH3 Deficiency on Sperm Energy Metabolism and Motility Leading to Asthenozoospermia. Biol Reprod. 2025,112:501-512

3. Wang Q#, Chi F#, Liu Y#, Chang Q, Chen S, Kong P, Yang W, Liu W, Teng X*, Zhao Y*,Guo Y*: Polyethylene microplastic exposure adversely affects oocyte quality in human and mouse. Environ International. 2025, 195:109236.

4. Liu Y#, Teng X#, Bai D#, Xing F, Chang Q, Li J, Gao S,* Liu W*, Guo Y*:Inhibition of aging-induced DNA hypermethylation by si-Dnmt3a_3b in pre-implantation embryos improves aberrant social beh**ior in offspring. International Journal of Biological Macromolecules. 2025 Mar 17;307(Pt 4):142130. 

5. Liu Y, Hao F, Liang H, Liu W, Guo Y*. Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice. Frontiers in Cell and Developmental Biology. 2025,13: 1562331

6. Jinli Li#, Tangzhen Zhao#, Mengmeng Ma, Pengcheng Kong, Yuping Fan, Xiaoming Teng*,Yi Guo*. Metabolomic profiling and machine learning-based biomarker identification for oligoasthenozoospermia. Metabolomics. 2025 Sep 17;21(5):137.

7. Yi Guo#, Mengxun Rong#, Yuping Fan, Xiaoming Teng, Liping Jin* and Yan Zhao*: The Presence of Microplastics in Human Semen and Their Associations with Semen Quality. Toxics. 2025 Jul 3;13(7):566.

8. Jie Zhang#, Shuwen Qiu#, Hongyuan Gao#, Xiaoyan Mao, Yi Guo* and Ling Wu*:Pregnancy and perinatal outcomes after modified natural cycle-frozen embryo transfers according to size of the dominant follicle on the hCG trigger day. Human Reproduction Open. 2025 Jul 16;2025(3).

9. Yang H#, Ma M#, Chen X, Chen G, Shen Y, Zhao L, Wang J, Yan F, Huang D, Gao H, Chen Y, Guo Y*, Liang B*, Teng X*: Multidimensional morphological analysis of live sperm based on multiple-target tracking. Comput Struct Biotechnol J. 2024, 24:176-184.

10. Guo Y#, Li J#, Hao F, Yang Y, Yang H, Chang Q, Kong P, Liu W, Jiao X*, Teng X*: A new perspective on semen quality of aged male: The characteristics of metabolomics and proteomics. Front Endocrinol (Lausanne). 2023, 13:1058250.

11.  Guo Y#, Bai D#, Liu W, Liu Y, Zhang Y, Kou X, Chen J, Wang H, Teng X*, Zuo J*, Gao S*. Altered sperm tsRNAs in aged male contribute to anxiety-like beh**ior in offspring. Aging Cell. 2021, 20(9):e13466.

12.  Li M, Chang Q, Luo Y, Pan J, Hu Y, Liu B, Ma M, Wang Q, Guo Y*, Wang Q*: The gut microbial composition in polycystic ovary syndrome with hyperandrogenemia and its association with steroid hormones. Front Cell Dev Bio.l 2024, 12:1384233.

13. Yi Guo#, Zhijuan Cao#, Xianting Jiao, Dandan Bai, Yalin Zhang, Jing Hua,Wenqiang Liu,Xiaoming Teng* Pre-pregnancy exposure to fine particulate matter (PM2.5) increases reactive oxygen species production in oocytes and decrease litter size and weight in mice. Environmental Pollution. 2021 Jan 1;268(Pt A):115858 

14.Guo Y#, Liu W#, Wang Y, Pan J, Liang S, Ruan J, Teng X: Polarization microscopy imaging for the identification of unfertilized oocytes after short-term insemination. Fertility and sterility.2017, 108(1):78-83.

15. Niu J, Chang Q, Xu J, Li J, Liu W, Chen Z, Jiao X, Guo Y*, Teng X*: Relationship of the levels of reactive oxygen species in the fertilization medium with the outcome of in vitro fertilization following brief incubation. Front Endocrinol (Lausanne). 2023, 14:1133566.

(1)**优选和检测方法、装置、电子设备及存储介质, 2023-09-29, 中国, 202310244206.8 (国家发明专利) 

(2) DNAH3 在制备弱精症诊断试剂或试剂盒以及治疗药物中的 应用, 2023-10-20, 中国, 202311364449.1 (国家发明专利)